Action mechanism
Down-regulated IL-17 reduces Th17 cells to prevent inflammation and angiogenesis and limit tumor growth
Mechanism of action: By regulating the pro-inflammatory immune cell population through the crosstalk between intestinal and liver tumors, the frequency of Th17 in the intestine can be reduced, and Th17 in the tumor microenvironment can be reduced, thus down-regulating the level of IL-17, and playing a role in delaying and controlling tumor growth
Prohep controls tumor growth in three ways
Down-regulated levels of interleukin (IL-17) and other pro-angiogenic factors
• IL-17 is a pro-inflammatory angiogenic factor
• Th17 is a major producer of IL-17 in the tumor microenvironment
• Prohep promotes the secretion of anti-inflammatory IL-10 cytokine and inhibits Th17 cell differentiation
Inhibit angiogenesis
• Angiogenesis is the process by which new blood vessels are created from existing ones, a process that is crucial for tumor growth
• HCC is a highly vascularized tumor, and reducing Th17 in the tumor weakens inflammation and angiogenesis and limits tumor growth
Down-regulated levels of interleukin (IL-17) and other pro-angiogenic factors
• IL-17 is a pro-inflammatory angiogenic factor
• Th17 is a major producer of IL-17 in the tumor microenvironment
• Prohep promotes the secretion of anti-inflammatory IL-10 cytokine and inhibits Th17 cell differentiation
Th1、Th2辅助细胞通过分泌IFN-y、IL-12等细胞因子，在抗感染、抗肿瘤反应中发挥重要作用
Th2细胞则通过分泌1L-4、1L-5、1-13等细胞因子促进机体的体液免疫应答、Treg细胞则在维护机体免疫平衡中发挥了重要作用
Th17细胞不表达儿-4或者IFN-y，但是通过高分泌炎症介质1L-17诱导自身免疫反应
IL-17是一种促炎血管生成因子，而肝癌是一种高血管化肿瘤，因此在肿瘤生长起重要作用
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